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Brandon McFadden GLP-1s such as semaglutide and tirzepatide found in drugs like Ozempic, Wegovy, Mounjaro and Zepbound were originally developed to manage blood sugar in people with type 2 diabetes

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Thus, conjugates with active GLP-1 made resistant to dipeptidyl peptidase-4 (DPP-4) and stably linked E2 were synthesized 16

This can lead to various uncomfortable symptoms, including a sticky or dry feeling in the mouth, difficulty swallowing or speaking, and a burning sensation on the tongue