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A meta-analysis also reported diagnoses of medullary thyroid carcinoma in patients taking GLP-1RAs, reinforcing the at-risk status as a contraindication to GLP-1RA treatment

Agri, 27:63-72

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Both medications are highly effective, but Tirzepatides dual-hormone mechanism (GLP-1 + GIP) may lead to faster or more significant weight-loss results for some individuals

However, GLP-1 agonists slow gastric emptying, which can affect the absorption of oral medications taken around the same time

Previous gastrointestinal issues : Mention any history of pancreatitis, gallbladder disease, gastroparesis, or severe gastrointestinal symptoms, as these may be contraindications or require additional monitoring