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Altria has struggled with lower shipment volumes and increased promotional investments, including a recent $0.17 per pack price increase on Marlboro and other brands in the U.S

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Since smoking is so prevalent in society and other nicotine-containing products such as vapes are increasingly consumed particularly by younger people, the aim of this narrative review is to compile the available information to better understand the processes by which nicotine alters sperm quality and sperm DNA/chromatin condensation