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That same month, the CDC identified vitamin E acetate, a chemical additive in e-cigarette products, as a likely culprit, though the agency noted additional chemicals could be involved

PMI subsequently expanded IQOS sales across the Far Eastern nation in 2016

Until then patients should not be misled into thinking that the likelihood of future harm is negligible when there is insufficient evidence to advocate this. At the moment, people who vape with e-cigarettes are guinea pigs, as nobody knows whether there are long-term risks to their health

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[3] This is the lowest recorded figure since the Ministry of Health, Labour and Welfare or Japan Tobacco began surveying in 1965