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Taken together, these observations support a hit-and-go model of R2 activity, in which transient R2-mediated targeting enables efficient integration, whereas prolonged effector activity compromises cellular fitness and genome stability

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Adults Black American adults had the lowest prevalence of e-cigarette use (2.4%) compared to White (5.2%), Hispanic (3.3%), and Asian American (2.9%) adults, according to the 2021 National Health Interview Survey