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The Global Burden of Disease 2004 Update (PDF)

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17 Furthermore, in a model of inhalational tolerance, prolonged cigarette smoke exposure of mice significantly delayed the establishment of tolerance induced by repeated harmless antigen challenges

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More intriguing than the impact of smoking on the severity of pre-established asthma, tobacco smoke appears to possess adjuvant properties in the initial recognition of allergens by the immune system, resulting in the induction of Th2 responses