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4.5 The Adverse Health Effects of Nicotine Nicotine replacement therapy has long been considered safe when used for smoking cessation or as long-term substitute for smoking by organisations that have strongly opposed the use of e-cigarettes (e.g

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Smoking also makes the blood clot together, which further hinders blood flow

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[16] Following advice from a working group set up by the Committee on Safety of Medicines (since 2005, the Commission on Human Medicines) the Medicines and Healthcare products Regulatory Agency (MHRA) concluded that nicotine replacement therapy products should be used also by those who are unable to stop abruptly