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According to a 2016 review in the American Journal of Public Health, jurisdictions across the U.S

the relative content of Methylobacterium on the surface of fresh tobacco leaves declined to some extent in the flue-curing process, and accounted for a large proportion in bacterial communities on the surface of flue-cured tobacco leaves

Treating tobacco use and dependence

Smoking cigarettes and commercial tobacco products use can weaken your immune system, making it harder for your body to fight off winter colds and illnesses

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See also p.32 of the report: Burning Issues: The Global State of Tobacco Harm Reduction 2020 Cigarette and HTP Sales in Japan - Burning Issues: The Global State of Tobacco Harm Reduction 2020 Heated tobacco products (HTP) now account for about a third of tobacco sales in Japan