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Additionally, p53 can activate apoptosis-related genes encoding death receptors like Fas (also known as APO1) and KILLER/DR5 (Death Receptor 5) [12,43]

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Firstly, the mixture was additionally moistened, and secondly, the essential oils of different tobaccos were actively mixed during this process, creating their own bouquet of flavors and aromas

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It highlights the importance of functional p53 in protecting skin cells from UVR damage, also suggesting that restoring wild-type p53 function could be a valuable strategy against skin cancer, especially non-melanoma skin cancers (NMSC)