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As smoking rates have declined in recent decades, so have rates of lung cancer, chronic obstructive pulmonary disease (COPD) and asthma

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It is generally acknowledged that it takes around fifteen years after quitting smoking for the risk of a prior smoker to approach that of someone who has never smoked

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30 Nicotine is metabolized primarily to cotinine, which is further metabolized to trans-3-hydroxycotinine (3HC), catalyzed by the liver cytochrome P450 2A6 enzyme

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