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[DOI] [PMC free article] [PubMed] [Google Scholar] Yamada H, Bruijnzeel AW

It's not so strong that I started coughing, but there was a definite satisfaction for this former long-time chain smoker

[DOI] [PubMed] [Google Scholar] 34.Cryan JF, Bruijnzeel AW, Skjei KL, Markou A

[16] Nicotine deregulates cardiac autonomic function, boosts sympathetic activation, raises heart rate, causes coronary and peripheral vasoconstriction, increases myocardial workload, and stimulates adrenal and neuronal catecholamine release

also, alcohol was tolerated (like placebo) over 5 d of natural drinking

Although some smokers can quit without help, many individuals need assistance in quitting