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Gene expression data suggested that SIMH was brought about by the downregulation of (1) the Fis1 gene which is needed for mitochondrial fission

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After fermentation, the leaves are aged in a cool environment (typically 65F) for anywhere from six weeks to six years to develop complexity

[PMC free article: PMC4515751] [PubMed: 20176308] Adsit RT, Fox BM, Tsiolis T, Ogland C, Simerson M, Vind LM, Bell SM, Skora AD, Baker TB, Fiore MC