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Future research to identify other susceptibility factors, such as genes that modify carcinogen metabolism or DNA repair, will need to be substantially larger and to quantify lifetime tobacco exposure with more precision than have past studies in order to distinguish gradations in risk due to exposure from those caused by genetic susceptibility

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Warfield, MD, a board-certified emergency medicine physician

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Bottom Line By 2010, the CDC hopes to reduce the proportion of smokers in the United States to 12%