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[63] [64] The most important chemicals causing cancer are those that produce DNA damage since such damage appears to be the primary underlying cause of cancer

The tobacco industry continues to develop and market products that perpetuate nicotine addiction while claiming reduced harm

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Importantly, nicotine itself doesnt require the tobacco leaf to exist it can be extracted from it or produced with high precision in a lab, ensuring consistency in strength and purity and opening the door to more modern methods of consumption

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In combination, these studies suggest that the biological mechanism underlying the association between cigarette use and alcohol use disorder cannot be automatically extrapolated to the relationship between smokeless tobacco use and alcohol use disorder