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One possible explanation for these regions of relative deactivation may be the shift from ventral to dorsal striatum that occurs as drug use becomes habitual and compulsive 29 , and the finding that dysfunctional inhibitory mechanisms in the prefrontal cortex also play a role in addictive behaviour 29, 30

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It is beyond the scope of this analytical method to draw correlations between ammonia concentrations in mainstream smoke and free nicotine or to determine if ammonia is the primary driver of smoke alkalinity

A hypersensitivity reaction to clozapine is believed to be the underlying biological mechanism for this series of conditions [28, 29]

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