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Routine screening is not currently recommended, but may be beneficial in individuals at high risk, such as heavy smokers

Potential mechanisms involved in this inflammatory response are hypoxia and cell death in the expanding adipose tissue, activation of the inflammation- and stress-induced kinases IB kinase- (IKK) and JUN N-terminal kinase (JNK), which further stimulate inflammation and insulin resistance [62]

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Fifteen drugs were extracted as risk factors, including nicotine, fluorouracil, sunitinib, aripiprazole, exenatide, antithymocyte immunoglobulin, sertraline, capecitabine, gemcitabine, granisetron, dexamethasone, bortezomib, sorafenib, cisplatin, and methylprednisolone

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