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State Tobacco in any form, vapor products (such as e-cigarettes) and electronic nicotine delivery systems, including but not limited to any product made or derived from tobacco and intended for human consumption, or likely to be consumed, whether smoked, heated, chewed, absorbed, dissolved, inhaled or ingested by any other means, including, but not limited to, a cigar, pipe tobacco, chewing tobacco, snuff and snus, and any component or accessor thereof, including but not limited to, a filter, rolling paper or pipe
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Moreover, total dendritic cells, macrophages, CD4 + , and CD8 + T cells increased significantly after smoke exposure, together with an upregulation in mRNA expression of CCL9 and CCL20, two important chemokines in CD pathogenesis (19) (Figure 1)
Chemicals such as carbon monoxide and cyanide in tobacco smoke reduce the elasticity of alveoli so the lungs can no longer fully exhale air
