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The relative risk for women who smoked cigarettes, depending on how much they smoked, was found to be between 2.2 and 4.6 (they were 2.2 to 4.6 times as likely to develop breast cancer)

This, along with a change in demand, accompanied the industrialization of cigarette production as craftsman James Bonsack created a machine in 1881 to partially automate their manufacture

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