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doi: 10.1089/ars.2016.6963

Other times, it affects both

Studies show that the chemicals within cigarettes, such as arsenic, nicotine, lead and ethyl phenol, could leach into salt and fresh water and be acutely toxic to aquatic micro-organisms and fish

neurological symptoms develop, such as muscle weakness, difficulty speaking, vision problems or loss of balance
In fact, chewing tobacco may even be more harmful than other forms of tobacco because it keeps the carcinogens in direct contact with your gums and teeth

That is expected, since cotinine only reflects recent exposure