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Therefore, additional interventions include mass media, workplace campaigns, and community programs could aid SLT cessation

34,37 The requirement for local metabolic activation of NNK in the mouse lung has been elegantly demonstrated by experiments using mice in which cytochrome P450-reductase, the requisite co-factor for cytochrome P450-catalyzed metabolic activation of NNK, has been knocked out in the lung, 38 and a polymorphism in Cyp 2A5 decreased NNK-induced DNA adduct formation and lung tumorigenesis, as seen in parallel epidemiologic studies of lung cancer

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doi: 10.1002/cncr.32073 30 PrinjaSDixitJGuptaNDhankharAKatakiACRoyPSet al