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Description
glauca , anabasine and nicotine, have both stimulant and depressant phases of action 9

This leads to an increased heart rate, developing the risk of a heart attack, coronary artery disease, and blood circulation problems

The oxidant/antioxidant imbalance may activate redox-sensitive transcription factors such as NF-B and activator protein-1, which regulate the genes of proinflammatory mediators (IFN) and protective antioxidants [22]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Wessler I., Kirkpatrick C.J
