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Furthermore, endothelial cells play a crucial role in maintaining the air-blood barrier and regulating inflammatory signaling in response to inhaled toxicants 11

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138 Lung-specific transgenic expression of VEGF induced, next to angiogenesis, edema, inflammation, vascular and parenchymal remodeling, a marked Th2 sensitization towards a model allergen, OVA.This was mainly attributed to epithelial and Th2-cell-derived VEGF