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55 Variants associated with nicotine dependence in the 5 / 3 / 4 gene region (chromosome 15, 15q25) also have a significant association with the number of cigarettes smoked per day, plasma levels of cotinine (a biomarker of nicotine intake), urine levels of tobacco-smoke carcinogens, and the risks of smoking-related diseases

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Box breathing (inhale 4, hold 4, exhale 4, hold 4) activates the parasympathetic nervous system (the bodys built-in calming response) without relying on substances