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Among smokers of 1-mg ISO tar cigarettes, those smoking split-tipping ECs had significantly lower MLE to tar and nicotine (4.1 mg/cig and 0.31 mg/cig, respectively) than those smoking control cigarettes (5.1 mg/cig and 0.40 mg/cig, respectively

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The potential exists for these clots to break away and embolize to other parts of the body, causing diseases such as stroke or ischemic bowel (loss of blood supply to part of the intestine)