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METHODS We searched published literature, government documents, media reports, the Tobacco Labelling Resource Center ( and tobacco industry documents ( between January 2010 and December 2011, beginning with the terms health warnings, warning clause, health notice, warning labels, warning, graphic country names, individuals, and Bates numbers of adjacent relevant documents using standard methods

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Therefore, we designed a multicenter, 12-week, randomized, placebo-controlled, double-blind study to compare the effectiveness of personalized doses of the nicotine patch (maximum of 84 mg/day) to standard 21 mg patch treatment in treatment-seeking adult smokers

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