soul trial oral semaglutide cardiovascular outcomes results 2025 European SOUL trial shows oral semaglutide

The theoretical benefit compared to the peptides is reduced receptor desensitisation and a different tolerability profile, though whether that translates to clinically meaningful differences in nausea, vomiting and discontinuation rates is still under investigation

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Bone microstructure High-resolution peripheral quantitative computed tomography (HR-pQCT) revealed declines in vBMD at both the radius and tibia, with particularly pronounced reductions in total and cortical vBMD at the tibia in postmenopausal women

The better response is continued consistency while evaluating specific factors systematically

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