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Large cardiovascular and obesity trials have provided reassurance regarding thyroid safety, but have not been designed to evaluate autoimmune-specific endpoints

Vos T, Lim SS, Abbafati C et al

Researchers are finding that GLP-1 agonists influence multiple pathways involved in inflammation, cardiovascular health, mood, motivation and rewardbenefits that appear to extend beyond the downstream effects of weight loss alone

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Exenatide has been observed to accumulate in the brain parenchyma of rodent models, and lixisenatide has demonstrated relatively rapid CNS penetration, likely due to its smaller size, lack of extensive protein binding, and susceptibility to endocytosis [70]
doi: 10.1053/joca.1999.0324
