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Semaglutide and tirzepatide injections are temperature-sensitive biologics that lose potency when exposed to freezing or excessive heat

Physiol Rep 2024;12:e16169

Its possible that employers, commercial insurers and payers in the public sectorincluding Medicaiddecide to eventually revisit their coverage decisions if net prices of GLP-1s decrease sufficiently, combined with more data showing the benefits of weight loss drugs when taken consistently and persistently in conjunction with an appropriate dietary and exercise regimen

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A SURPASS-2 trial compared tirzepatide to semaglutide in patients already taking metformin, and found that tirzepatide led to greater reductions in HbA1c (a measure of average blood sugar levels) and body weight compared to semaglutide