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Early data suggests that some risks, particularly diabetic retinopathy worsening, appear highest in the first three to six months of treatment

KFFs report notes an increase in spending on GLP-1 drugs in Medicaid programs starting in 2021

Tirzepatide: Quick Comparison Which Medication Produces More Weight Loss

Another important consideration when evaluating the impact of these medications on bone health outcomes is the sustainability of GLP1Ra use as weight regain following cessation of treatment is expected (Quarenghi et al., 2025)

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These prespecified analyses considered factors such as age, hypertension, heart failure, eGFR, proteinuria, new users after the index day, enrollee after 2006 and concurrent usage of other medications for glycemic control, and renin-angiotensin-aldosterone system (RAAS) blockers