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So, what is the safety with biologics, methotrexate and GLP-1s

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While physical dependence at prescribed doses is uncommon, the classification carries stigma and prescribing restrictions

Interestingly, glucose-dependent insulinotropic polypeptide levels were not sex divergent in the same study, suggesting that among incretins GLP-1 may be more prone to sex differences, at least in the setting tested
Geroscience 42 , 667686 (2020)

Why Canadian Patients Choose Compounded GLP-1 Over Brand Options Brand-name semaglutide (Ozempic, Wegovy) and tirzepatide (Zepbound, Mounjaro) typically cost $300$500 per month in Canada without insurance coverage, and many patients face multi-month wait times through provincial health systems
