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This gives the brain more time to adapt to each new dose level before introducing another change

Remember, the drugs slow down the emptying of the stomach into the small intestine, and that can lead to things getting backed up further down the line, Kessler says

Results from a blood-oxygen dependent functional MRI study [44] also suggest that mesolimbic reward-related areas may also mediate the anorectic effects of Ex in humans, with a hypothesised mechanism of decreasing responsiveness to contextual food cues (incentive salience, wanting) and increasing activity that correlates with consummatory reward value (liking) [45]

Malila, Y., Owolabi, I

The doses are different also

Phentermine follows a similar pattern of regain, though the data is less precisely quantified because the shorter treatment duration and older study designs make direct comparisons difficult