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24 A more recent double-blind, randomized, controlled trial that investigated the microvascular effects of linagliptin in nondiabetic patients with arterial hypertension resulted in a significant improvement in retinal capillary perfusion and retinal arterial blood flow

The results showed that during the 16-week treatment period, patients who received the highest dosage (120 mg twice daily) of danuglipron experienced an average reduction in HbA1c of 1.16 percentage points and a weight loss of 4.17 kilograms

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doi: 10.1186/1471-2202-13-33 [DOI] [PMC free article] [PubMed] [Google Scholar] 121.Yang Y, Zhang J, Ma D, et al

Thirdly, the COVID-19 pandemic significantly impacted the study, with the majority of participants either randomised just before the pandemic or reaching the critical 6 month and 12-month trial milestones during the pandemic