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low long-term adherence with subsequent weight regain

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Several medications have entered phase 2 or 3 of clinical trials for PWS patients ( and this therapeutic approach of appetite modulation via the hypothalamus could provide promising results not only in PWS patients, but also for patients with other types of hypothalamic obesity

As weight gain is a significant problem for women with breast cancer, particularly those receiving chemotherapy and endocrine therapy, safe and effective weight loss drugs for this population are urgently needed

(10) However, the positive effects of obesity on bone formation are nullified by the simultaneous induction of functional osteopenia, in a phenomenon known as the obesity paradox

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