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Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review

Tier 2 and Tier 3 weight management services provide intensive support Dietetic input : Specialist dietitians can develop individualised plans accommodating Crohn's-related dietary restrictions whilst achieving caloric deficit Psychological support : Cognitive behavioural therapy and motivational interviewing address eating behaviours and emotional factors Physical activity programmes : Tailored exercise plans considering Crohn's-related fatigue and extra-intestinal manifestations Bariatric surgery represents the most effective long-term weight management intervention for severe obesity

Tirzepatide is a dual agonist that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, while other medications in this class activate only GLP-1 receptors

2011;301(2):F355F363

Glucagon-like peptide-1 receptor agonist in myocardial infarction and atherosclerotic cardiovascular disease risk reduction: a comprehensive meta-analysis of number needed to treat, efficacy and safety

As a generic drug, its an inexpensive option, says Lazarus