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Tirzepatide at the 5mg starting dose produces measurable weight loss within weeks for many patients, with average reductions of 5-8% body weight in early clinical studies

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Semaglutide is safe to use in CKD stage 4 (eGFR 15-29 mL/min/1.73 m) without dose adjustment, and should be initiated at standard dosing (0.25 mg weekly, ti...

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