glp 1 for diabetes Patients Also Struggle to Access GLP-1 Agonists How GLP-1 medications are transforming

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You think of them as having effects in the pancreas, but it turns out they're brain drugs. A recent study involving semaglutide a type of GLP-1 analog used in medications like Ozempic and Wegovy indicated the drug altered the way lab mice approached running on a wheel, a behavior akin to exercise

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Prescribing information (Novo Nordisk, 2025)

GIP and GLP-1 are also synthesized in the brain

To verify that liraglutide-induced circulating FGF21 originates from the liver, we administered vehicle and liraglutide to fasted control mice and mice lacking liver PPAR, a key regulator of liver FGF21 production