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The result is a narrower therapeutic windowyour body may experience a brief period of strong GLP-1 receptor activation followed by hours or days of lower drug concentration

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Such evidence now explicitly informs the NRDL dynamic adjustment process, particularly regarding the inclusion and pricing of high-cost innovative medicines [36]

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The downstream consequences are real: shifted oral pH, plaque accumulation, dry mouth, enamel sensitivity, and elevated risk for gingivitis and periodontal disease