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How do GLP-1 weight loss drugs affect the liver

Those with a history of arrhythmias, uncontrolled hypertension, coronary artery disease, or previous cardiac events should approach this combination with extreme caution

It is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA in May 2022

J Clin Endocrinol Metab (2021) 106:301933

In an aspect of the present invention, peptide having the amino acid sequence His- Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu- Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly has the formula His-Aib-Glu-Gly-Thr-Phe-Thr- Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg- Gly-Arg-Gly-Resin wherein the amino acids of the sequence are optionally protected with protecting group(s)

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