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Tirzepatide warnings and precautions According to the FDA, there were some serious health issues that occurred in clinical trials of people taking tirzepatide, including: Pancreatitis Hypoglycemia Hypersensitivity reactions Acute kidney injury Severe gastrointestinal disease Diabetic retinopathy complications Acute gallbladder disease These are listed as precautionary because they were reported in a clinical trial, but there is not yet evidence that use of tirzepatide caused these issues

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JAMA, 333 (8), 652655

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