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Taking metformin with meals and ensuring adequate hydration may also reduce gastrointestinal discomfort

For example, focusing too much weight on one leg when you stand can lead to excessive stress on your hip joint, causing deterioration and pain, or consistently slouching in a desk chair can put excess stress on your spine and lower back muscles
However, this is an inherent limitation of large real-world datasets, and such misclassification is likely non-differential, biasing results toward the null

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