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They work by mimicking the effects of the naturally occurring hormone called glucagon-like peptide-1 (GLP-1), which is responsible for regulating insulin and blood sugar levels

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Key pathways, including Wnt/-catenin, bone morphogenetic protein 2/Smad, phosphoinositide 3-kinase/Akt and protein kinase A, play a role in this

And when progress slows, patients look elsewhere