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World Journal of Gastroenterology, 27 (45), 77847791

announced that the FDA has approved WEGOVY as the first GLP-1 receptor agonist for adults with Metabolic Dysfunction-associated Steatohepatitis (MASH) who have moderate to advanced fibrosis, excluding In August 2025, Novo Nordisk cirrhosis , in combination with diet and exercise

However, underlying insulin resistance drives many of the syndromes clinical manifestations, including weight gain and increased risk for type 2 diabetes

Had we assessed risk of bias for less objective outcomes, such as participant-reported gastrointestinal adverse events, overall risk of bias for such outcomes in these trials might have been deemed of some concern

Others are located in the dorsal raphe nucleus, which produces nearly all of the serotonin used by the forebrainthe same neurotransmitter system targeted by selective serotonin reuptake inhibitors