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EAC=external adjudication committee

Tirzepatide influences pathways related to appetite and glucose regulation

The observed effects were consistent in all investigated subgroups, with a trend toward stronger effects in subjects with T2D and higher cardiovascular risk (77)

Sample meals for days 5-7: Breakfast: High-protein breakfast sandwich (25g protein, easy 3-minute prep) Mid-morning: Small apple with 1 tablespoon almond butter Lunch: Turkey and avocado wrap (3 oz turkey, small whole wheat tortilla, avocado, veggies) Afternoon: cup cottage cheese with cucumber slices Dinner: 4 oz lean ground turkey, cup pasta, marinara sauce, side salad Progress check: By day 7, you should have a sense of what portion sizes work for you, which foods you tolerate well, and what your new "satisfied" feels like

Loss of CNS GIPR augments weight loss with GLP-1R agonism To examine whether CNS GIPR is required for the additive weight loss effect of combination treatment with mGIPR-Ab and clinically approved GLP-1R agonists, HFD-fed Gipr fl/fl control mice and Gipr Syn/ mice received IP dosing of either vehiclevehicle, dulaglutidevehicle or dulaglutidemGIPR-Ab combination treatments

The samples were subsequently rehydrated in a methanol and PBS series: 80%, 60%, 40% and 20%, with 0.2% Triton X-100, 1 h each at room temperature