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The black box warning for semaglutide is based on animal studies where rats and mice developed thyroid tumors, including a rare type of thyroid cancer called medullary thyroid carcinoma (MTC)

Highlights of Prescribing Information Wegovy (semaglutide)

Billy Wilkins, Robert S

Most patients do not see measurable scale weight loss in week one, even though the medication is actively reducing appetite

and injecting it into the area where volume or contour restoration is desired

The FDA prescribing information for weight management formulations (Wegovy, Saxenda) includes warnings about monitoring for suicidal thoughts or behaviors