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GLP-1 mediates its effects by binding to its receptor, the GLP-1 receptor (GLP-1R), which is a G proteincoupled receptor that is abundantly present in the pancreatic beta cells, gut, and the central nervous system (CNS) and moderately in the lung, heart, kidney, blood vessels, pancreatic alpha cells, and peripheral nervous system 2,4,7

Female patients of child bearing age should be counselled about contraception because of how AOM reduces gastric emptying and can reduce the efficacy of oral contraception on initiation and uptitration

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Further investigations have identified a novel compound, tetrahydrofuran (THF), as a key player indicating the effective PL inhibitor

Retatrutide is not currently approved by the European Medicines Agency (EMA) and is therefore not legally available in the Netherlands

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