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Whilst there is no evidence suggesting harm from combining these products, the absence of specific interaction studies means we cannot make definitive claims about safety in all circumstances

Improvements in steatosis and hepatocyte ballooning scores were also observed

Sustainable results depend more on a comprehensive, individualized care plannot medication alone.

Conclusions/interpretation A dose-dependent superiority on glycaemic efficacy and body weight reduction was evident with tirzepatide vs placebo, GLP-1 RAs and basal insulin

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Calorically dense substances, including alcohol, carry reinforcing properties going beyond their central nervous system effects