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The peptide incorporates a C20 fatty diacid moiety via a Glu-(AEEA) linker enabling reversible albumin binding and an extended pharmacokinetic profile compatible with once-weekly dosing

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Note This is an online update of the original version of this article that was published in the September 2025 issue of Medicine Today

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Therefore, given the emerging evidence for non-anatomic contributors to OSA pathophysiology, as well as the advent of anti-obesity pharmacotherapy [16], the therapeutic landscape for the personalized management of OSA has evolved over the last decade

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Monitor Changes and Discuss With Your Clinician

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not a maintenance dose) Weeks 58: 5 mg once weekly Then: consider +2.5 mg increments (e.g., 7.5 10 12.5 15 mg) no sooner than every 4 weeks, if appropriate and tolerated Maintenance target: 5 mg, 10 mg, or 15 mg once weekly, chosen by your clinician based on response and side effects This gradual approach is designed to reduce the risk of gastrointestinal (GI) side effects during dose changes and allow time to evaluate how youre doing at each step

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