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Thats nearly a 1600x increase in cost which few diabetes patients would find feasible

Nearly one in four pounds, gone

Although many newer antipsychotics (eg, brexpiprazole, cariprazine, lumateperone, pimavanserin, and xanomeline-trospium) tend to be costly or require prior authorization for insurance coverage, they may be preferred after undergoing a personalized cost-benefit analysis

Dutta D et al (2021) Efficacy and safety of novel twincretin tirzepatide a dual GIP and GLP-1 receptor agonist in the management of type-2 diabetes: A Cochrane meta-analysis

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The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: Checklist and explanations