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Conclusions/interpretation Approximately half of type 2 diabetes patients who had started using GLP-1 receptor agonists or SGLT2 inhibitors had discontinued treatment within 5 years of follow-up

When switching between GLP1RAs, transient GI AEs are expected and can be reduced by slow uptitration, including use of intermediary doses, and advising patients to reduce portion sizes and fat intake

Those Who Want Long-Term Health and Metabolic Balance Small improvements in how the body handles insulin and controls appetite can lead to positive outcomes over time

It increases insulin secretion, enhances glucose absorption by skeletal muscle cells, and decreases inflammation, all of which contribute to improved metabolic health

If you do drink, do so with food, slowly, and in moderation and never on an empty stomach

Survodutide's partnership with Boehringer Ingelheim provides a clear development and commercialization advantage, while pemvidutide's lean mass preservation data and alcohol use disorder expansion could provide meaningful differentiation in a crowded market