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Endocrine 57 , 464473
But proponents of the medications have pointed out that some people cant achieve a healthy weight through diet and exercise alone, perhaps due to factors like genetics or stress
This phenomenon is known as Paxlovid rebound

Natural GLP-1 has a half-life of about 23 minutes, it's released, it acts, and it's broken down almost immediately by the enzyme DPP-4, which degrades 50% of circulating GLP-1 within 1-2 minutes
